O-GlcNAc and the cardiovascular system
نویسندگان
چکیده
منابع مشابه
O-GlcNAc signaling in the cardiovascular system.
Cardiovascular function is regulated at multiple levels. Some of the most important aspects of such regulation involve alterations in an ever-growing list of posttranslational modifications. One such modification orchestrates input from numerous metabolic cues to modify proteins and alter their localization and/or function. Known as the beta-O-linkage of N-acetylglucosamine (ie, O-GlcNAc) to ce...
متن کاملO-GlcNAc Modification: Friend or Foe in Diabetic Cardiovascular Disease
O-Linked β-N-acetyl glucosaminylation (O-GlcNAcylation) is a dynamic post-translational modification that occurs on serine and threonine residues of cytosolic and nuclear proteins in all cell types, including those involved in the cardiovascular system. O-GlcNAcylation is thought to act in a manner analogous to protein phosphorylation. O-GlcNAcylation rapidly cycles on/off proteins in a time sc...
متن کاملExploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain.
The covalent modification of intracellular proteins by O-linked beta-N-acetylglucosamine (O-GlcNAc) is emerging as a crucial regulatory posttranslational modification akin to phosphorylation. Numerous studies point to the significance of O-GlcNAc in cellular processes such as nutrient sensing, protein degradation, and gene expression. Despite its importance, the breadth and functional roles of ...
متن کاملX-inactivation normalizes O-GlcNAc transferase levels and generates an O-GlcNAc-depleted Barr body
O-GlcNAc Transferase (OGT) catalyzes protein O-GlcNAcylation, an abundant and dynamic nuclear and cytosolic modification linked to epigenetic regulation of gene expression. The steady-state levels of O-GlcNAc are influenced by extracellular glucose concentrations suggesting that O-GlcNAcylation may serve as a metabolic sensor. Intriguingly, human OGT is located on the X-chromosome (Xq13) close ...
متن کاملO-GlcNAc cycling modulates neurodegeneration.
A ge-associated neurodegenerative diseases are not only a great scientific challenge but a medical, economic, and social burden of enormous dimensions. This family of diseases includes Alzheimer’s (AD), Parkinson disease, Huntington disease, and others, among which AD is the most common. AD alone affects more than 35 million people worldwide. Although these disorders are products of different e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmacology & Therapeutics
سال: 2014
ISSN: 0163-7258
DOI: 10.1016/j.pharmthera.2013.11.005